Long plane ride. What are my options?

I would like to go to Bresil but from where I live it’s a pretty long flight (around 14 hours) which I could try to do with a layover but I’m wondering if that’s better or worse? Like it would be shorter to go in one go but also complete torture!

I would also appreciate any tips on traveling long distance with RLS. I’m not sure what I can do to help myself. When I go on long car rides I usually put a big cold coke bottle at my feet so I can roll my feet on it and I try to keep my mind occupied. I lay off the sugar/glucose and try to keep an active lifestyle before going as I noticed this helps.