Iconic Sounds in Film History?

TL;DR - What sounds or sound design nailed a sound or created a new sound that immediately became iconic?

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I just rewatched Oblivion, and the sound design of the drones has got to be one of the best executed sounds in film history, and it's just astonishing to hear on a good system.

Then I go back to my favorite franchise and realize Alien has brought so many unreal sounds for film history: MUTHR waking up at the start of Alien, the motion tracker in Aliens. Scott must love sound design because it's the same with Blade Runner and various clicks and chirps.

Recently, Eggers' work in Nosferatu is BONKERS with that sound design, and Orlock's breathing. The whole film is wild to listen to.

So what sound design or sounds from cinema stick with you, and were sort of a revolution in nailing a sound, or creating something amazing. I realize I often like the sound design more than the film itself! =)