uOPL Neutrino exfat HDD

Hey guys.

Sorry if this question is dumb but... Is it possible to use Neutrino to run PS2 games from an exfat internal hard drive via uOPL? I have seen people using Neutrino with exfat HDDs, but not with uOPL. I want to know whether it is possible or not to do the same but using uOPL to launch Neutrino.