I Love/Hate Webbers

When fully charged, they can deal a Nuts-Eradicating hit, otherwise, it is but a Nuts-Tickling experience.

Are there skills that I should get when using Webbers? I am trying to use them consistently, but even when I do One-shot some things, others are just unfazed.

Also, the hits don't go through Aegis, Shield or Reflectors, right?